Nerve Growth Factor (NGF) Nourishment

May 29, 2025

Lion’s Mane’s hericenones and erinacines have been suggested in research to promote nerve growth factor (NGF) synthesis.

Lion’s Mane’s hericenones and erinacines have been suggested in research to promote nerve growth factor (NGF) synthesis.
Nerve growth factor is suggested to help the brain in many ways, including:

• Helping the growth and health of brain cells and nerves throughout the body
• Playing key roles in neurogenesis, which refers to the creation of fresh new neurons
• Promoting brain plasticity: New neural connections that underlie memory and learning
• Supporting myelin, the fatty sheathing that surrounds and protects nerves Inadequate nerve growth factor levels have been linked to low mood, cognitive decline and memory issues
• Plays a role in supporting healthy brain injury recovery.

The NGF-boosting bioactivity this mushroom offers is a rare find among supplements. It is highly desirable due to the benefits on brain and nerve health and mental performance.

The best lion’s mane mushroom supplements offer foundational support for memory, mood and overall cognition. They are also suggested to help reduce brain fog in cases of mild age-related cognitive decline.

Lion’s mane is increasingly researched for its ability to nourish the brain and optimize some cognitive abilities. Most studies are animal trials, but some promising human studies have also been carried out.

Let’s take a closer look at some of the research behind lion’s mane.

Mental Clarity in Age-Related Decline

Lion’s mane may improve mental performance in those with mild cognitive impairment.

In one double-blind, placebo-controlled clinical trial, subjects aged 50-80 took Lion’s Mane Mushroom or placebo three times a day for 16 weeks.

Researchers found that the Lion’s Mane supplementation was associated with enhanced cognitive performance scores, and that cognitive testing scores dropped four weeks after supplementation ceased.

The researchers concluded that Lion’s Mane may be a helpful therapy in cases of mild cognitive impairment.